Yep its well possible, you can assign the button box like any other controller from the ingame menu. i havent done any quickchat keys cos i dont really use them.
That layout plan is just what i thought works for me, allthough i changed allready the lcd mode to the middle of
the other lcd controls, and where it used to be lcd mode i use not enable/disable hw plugins.. might add some
extra switches today for reset FFB, vehicle labels and seat adjustment

EDIT:Added couple extra switches on the top, that means the box has 17 switches, and my wheel has 18 (for now, not after modding).. That means i can assign 35 buttons to different actions.. never have to reach keyboard while
racing thats for sure! should be enought and little extra too.

